Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

Amino acids from ion-irradiated nitrile-containing ices.

Solid CH(3)CN and solid H(2)O + CH(3)CN were ion irradiated near 10 K to initiate chemical reactions thought to occur in extraterrestrial ices. The infrared spectra of these samples after irradiation revealed the synthesis of new molecules. After the irradiated ices were warmed to remove volatiles, the resulting residual material was extracted and analyzed. Both unhydrolyzed and acid-hydrolyzed...

Reactions of Diiron μ-Aminocarbyne Complexes Containing Nitrile Ligands

Dipole-bound anions of carbonyl, nitrile, and sulfoxide containing molecules

Dipole-bound anions of 27 molecules containing either a carbonyl, nitrile, or sulfoxide group were studied using Rydberg electron transfer ~RET! reactions with rubidium atoms excited to ns S and nd D excited states. The electron affinity of each molecule was obtained from the Rydberg state, nmax * , that gave the largest negative ion yield using the empirical relationship electron affinity5 23/...

Magnesium-catalysed nitrile hydroboration

A b-diketiminato n-butylmagnesium complex is presented as a selective precatalyst for the reductive hydroboration of organic nitriles with pinacolborane (HBpin). Stoichiometric reactivity studies indicate that catalytic turnover ensues through the generation of magnesium aldimido, aldimidoborate and borylamido intermediates, which are formed in a sequence of intramolecular nitrile insertion and...

Unraveling the catalytic mechanism of nitrile hydratases.

To elucidate a detailed catalytic mechanism for nitrile hydratases (NHases), the pH and temperature dependence of the kinetic constants k(cat) and K(m) for the cobalt-type NHase from Pseudonocardia thermophila JCM 3095 (PtNHase) were examined. PtNHase was found to exhibit a bell-shaped curve for plots of relative activity versus pH at pH 3.2-11 and was found to display maximal activity between ...